Takeda researchers discovered ROZEREMTM(ramelteon) (then TAK-375) in 1996. In 2005, the U.S. Food and Drug Administration approved ROZEREM 8 mg tablets for the treatment of insomnia characterized by difficulty with sleep onset. ROZEREM was approved for long-term use in adults. ROZEREM is the first and only prescription sleep medication that has shown no evidence of abuse* and dependence in clinical studies, and, as a result, has not been designated as a controlled substance. ROZEREM is the first prescription insomnia medication with a new therapeutic mechanism of action in 35 years.
ROZEREM has a unique therapeutic mechanism of action that selectively targets two receptors located in the brains suprachiasmatic nucleus (SCN). The SCN is known as the bodys "master clock" because it regulates 24-hour, or circadian, rhythms, including the sleep-wake cycle.
ROZEREM is indicated for the treatment of insomnia characterized by difficulty with sleep onset. ROZEREM can be prescribed for long-term use. ROZEREM should not be used in patients with hypersensitivity to any components of the formulation, severe hepatic impairment, or in combination with fluvoxamine. Failure of insomnia to remit after a reasonable period of time should be medically evaluated, as this may be the result of an unrecognized underlying medical disorder. Hypnotics should be administered with caution to patients exhibiting signs and symptoms of depression.
ROZEREM has not been studied in patients with severe sleep apnea, severe COPD, or in children or adolescents. The effects in these populations are unknown. Exercise caution if consuming alcohol in combination with ROZEREM.
ROZEREM has been associated with decreased testosterone levels and increased prolactin levels. Health professionals should be mindful of any unexplained symptoms possibly associated with such changes in these hormone levels. ROZEREM should not be taken with or immediately after a high-fat meal. ROZEREM should be taken within 30 minutes before going to bed and activities confined to preparing for bed.
The most common adverse events seen with ROZEREM that had at least a 2% incidence difference from placebo were somnolence, dizziness, and fatigue.
For complete prescribing information, please visit www.rozerem.com or view the ROZEREM Complete Prescribing Information.
Sounds interesting.
Jeff
That is interesting, thank you, I have been concerned about the seroquel I'm on, side effects I've read about.
Wonderwoman you shouldhave your blood drawn 2-3 months to check for elevated levels-
Jeff
Jeff
Hey all, thanks for the info on the medication Jeff,I will speak to my Doctor about it. I have been on Imovane for the last two years and would love to come off of it but am worried about the withdrawals.
I don't ever have my blood tested to see what the levels are, do you think I should? what should I ask the Doctor to test for?
Take care.
Karen
I don't ever have my blood tested to see what the levels are, do you think I should? what should I ask the Doctor to test for?
Take care.
Karen
wonderwomen, I am on seroquel as well. They say that is has not been studied for abuse in humans, I believe I read that anyway, but I have heard about people crushing it up and snorting it. ECH! I cant imagine why anyone would want to do that I hate the way it makes me feel. But I can def see it's potential for abuse, if you have ever taken large amounts of it and are able to saty awake it def gives you weird feelings. I have also read some of it's side effects can be awful, but I believe that I read they only show in 10% of patients studied, and most did not get the real bad ones, also these patients were taking very high doses. Originally my dr perscribed me up to 800 mgs, and then my psychiatrist lowered it to 200 mgs to be taken with 1000 mgs of depakote and 2 mgs of xanax, as 800 mgs of seroquel is alot, and I felt like I freaking zombie. I then read that 800 mgs was shown to cause brain damage!
Karen you should ask your doctor to run a full panel lipids tests evreything. Make sure you specifically ask for your cholesterol godd-bad and the average.
Lots of doctors are hesitant to run any extra blood tests you need to ask.
Tell the doctor all the meds you have taken for how long and then say test for any potential side effects.
Be aggressive or they will do the minimum generally.
Good luck--Jeff
Lots of doctors are hesitant to run any extra blood tests you need to ask.
Tell the doctor all the meds you have taken for how long and then say test for any potential side effects.
Be aggressive or they will do the minimum generally.
Good luck--Jeff
